Phages reconstitute NAD+ to counter bacterial immunity
Millman, A. et al. An expanded arsenal of immune systems that protect bacteria from phages. Cell Host Microbe 30, 1556–1569
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Animals Six- to eight-week-old female CD45.2+Thy1.2+ C57BL/6 (C57BL/6J) mice, CD45.1+ mice (B6.SJL-Ptprca Pepcb/BoyCrl) and NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were purchased
Transferrin receptor targeting chimeras for membrane protein degradation
Mayle, K. M., Le, A. M. & Kamei, D. T. The intracellular trafficking pathway of transferrin. Biochim. Biophys. Acta 1820,
Bendable non-silicon RISC-V microprocessor | Nature
In this section, we describe the microarchitecture of the C-SPI IP block, the ML hardware accelerator, the new instructions to
Brazilian fossils reveal homoplasy in the oldest mammalian jaw joint
Luo, Z.-X. & Manley, G. A. in The Senses: A Comprehensive Reference Vol. 2 (eds Fritzsch, B. & Grothe, B.)
Single-cell multi-omics map of human fetal blood in Down syndrome
Ethics and tissue acquisition Human fetal bone and liver samples were obtained from 15 fetuses with Ts21 12–20 post-conception weeks
AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
Zhang, D. et al. Metabolic regulation of gene expression by histone lactylation. Nature 574, 575–580 (2019). Article ADS CAS PubMed
How I apply Indigenous wisdom to Western science and nurture Native American students
Changemakers This Nature Q&A series celebrates individuals who have fought racism in science and who champion inclusion. The series often
Jet stream controls on European climate and agriculture since 1300 ce
Stendel, M., Francis, J., White, R., Williams, P. D. & Woollings, T. in Climate Change 3rd edn (ed. Letcher, T.
Designed endocytosis-inducing proteins degrade targets and amplify signals
Computational design of sortilin minibinders as Sort_EndoTags Using a Rosetta-based binder design protocol15, 21,000 binders were generated to each of