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Structural basis for pegRNA-guided reverse transcription by a prime editor

Sample preparation The PE2 (nSpCas9–engineered M-MLV RT), Cas9 (H840A) and M-MLV RTΔRNaseH (D200N/T306K/W313F/T330P) genes were PCR-amplified from pCMV-PE2 (Addgene plasmid

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Natural killer cells show their cancer-fighting worth

Oncologist Todd Fehniger researches natural-killer-cell therapy for use in cancer treatment.Credit: David Russler-Germain As part of a study published in

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Unlocking bacterial potential to reduce farmland N2O emissions

Robotized batch cultivations for respiratory phenotype NNRB have attracted much interest recently as net sinks for N2O in soils, potentially

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AI assistance for planning cancer treatment

Oncologists face a conundrum with immunotherapies. These drugs are designed to smash through the immunity-suppressing fog created by tumours. When

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A vision chip with complementary pathways for open-world sensing

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Baobab trees’ evolutionary history could inform conservation efforts

RESEARCH BRIEFINGS 29 May 2024 The genomes of all eight living species of baobab tree (Adansonia sp.) reveal the group’s

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Van der Waals polarity-engineered 3D integration of 2D complementary logic

Kang, J.-H. et al. Monolithic 3D integration of 2D materials-based electronics towards ultimate edge computing solutions. Nat. Mater. 22, 1470–1477

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Autism triples risk of Parkinson’s-like symptoms

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. In

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Streamflow seasonality in a snow-dwindling world

Bintanja, R. & Andry, O. Towards a rain-dominated Arctic. Nat. Clim. Change 7, 263–267 (2017). Article  ADS  Google Scholar  Barnett,

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Canted spin order as a platform for ultrafast conversion of magnons

Theoretical description Derivation of the nonlinear torque We developed a model for the generation of the propagating magnons in the