Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T<sub>reg</sub> cells
Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07121-9 A high baseline of intratumoural macrophages and regulatory T cells is associated with
The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
Cell culture HeLa (CCL-2) cells were obtained from Sigma-Aldrich. HEK293T cells were a gift from D. Trono (EPFL), originally purchased
Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome
Bacterial strains and growth conditions The Mtb H37Rv strain (obtained from C. Sassetti) was grown at 37 °C in a minimal medium (Difco Middlebrook
Mutualisms weaken the latitudinal diversity gradient among oceanic islands
Datasets Regional plant distribution data along with explanatory variables were extracted from the GIFT v3.0 database3 using the GIFT R
Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing
Molecular cloning and mRNA production ETRs were transiently delivered as either plasmid DNA (in cell lines) or mRNA (in cell
Private Moon lander is dying — it scored some wins for science
Leaning on its side in the fading sunlight near the Moon’s south pole, the first commercial spacecraft to soft-land on
How dwarf galaxies lit up the Universe after the Big Bang
An illustration of the reionization of the Universe, which transitioned from a cauldron (red, right) of subatomic particles to a
Mechanisms of calcium homeostasis orchestrate plant growth and immunity
White, P. J. & Broadley, M. R. Calcium in plants. Ann. Bot. 92, 487–511 (2003). CAS PubMed PubMed Central Google
Crym-positive striatal astrocytes gate perseverative behaviour
Mouse models All animal experiments were conducted in accordance with the National Institutes of Health (NIH) Guide for the Care