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Targeted protein degradation via intramolecular bivalent glues

Chemical synthesis Additional details are provided in the Supplementary Methods. Plasmids and oligonucleotides The design and construction of the human CRL-focused

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‘brain drain’ is derailing the fight to stop them

Infections caused by drug-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (yellow) are responsible for hundreds of thousands of deaths worldwide.Credit:

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How egg cells handle their cellular rubbish

Mouse egg cells contain specialized ‘recycling bins’ that help to keep cells tidy before fertilization1. Access options Access Nature and

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Reducing carbon dioxide efficiently to reuse and recycle it

RESEARCH BRIEFINGS 21 February 2024 Electrochemical reduction of carbon dioxide holds promise for converting CO2 into valuable products but is

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Why citizen scientists are gathering DNA from hundreds of lakes — on the same day

The LeDNA project will disperse hundreds of volunteers to sample environmental DNA from the world’s lakes.Credit: K. Deiner In a

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B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4

Mice C57BL/6J, Aireflox/flox, Rag1−/−, Cd40−/− and Tcra−/− mice were obtained from Jackson Laboratories and bred in our facility. Aqp4−/− mice

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A lanthanide-rich kilonova in the aftermath of a long gamma-ray burst

Eichler, D., Livio, M., Piran, T. & Schramm, D. N. Nucleosynthesis, neutrino bursts and γ-rays from coalescing neutron stars. Nature

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Directive giant upconversion by supercritical bound states in the continuum

Theory In the section ‘TCMT: critical coupling for an isolated mode’, the local field enhancement at critical coupling for an

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Claus Nielsen (1938–2024), zoologist of invertebrates

Credit: Leonid L. Moroz Unravelling the winding paths that evolution has taken is a daunting task. Claus Nielsen was one

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Fractional quantum Hall effect at zero magnetic field observed in an unexpected material

RESEARCH BRIEFINGS 21 February 2024 The fractional quantum anomalous Hall effect occurs when the Hall resistance in a material is